Suzuki H, Mori M, Kai A, Suzuki M, Suematsu M, Miura S, Ishii H
Department of Internal Medicine and Biochemistry, School of Medicine, Keio University, Tokyo, Japan.
Dig Dis Sci. 1998 Sep;43(9 Suppl):181S-187S.
Helicobacter pylori colonized to gastric mucosa plays an important pathogenic role in gastric mucosal lesions. We previously reported that ethanol pretreatment promotes the extension of H. pylori-associated lesions. The present study was designed to examine the effect of rebamipide, a mucosal protective agent, on H. pylori-associated injury. Male Mongolian gerbils were orally inoculated with H. pylori; 30 min prior to inoculation, 40% ethanol was administered orally to these gerbils (Hp group). Controls were given 40% ethanol with culture medium (control group). Some gerbils in the Hp and control groups were fed rebamipide-containing diets, and the remaining gerbils received laboratory chow diets. H. pylori infection was evaluated by quantitative bacterial culture and histological examination. Although H. pylori was persistently detected and a remarkable mucosal leukocyte infiltration was observed in the Hp groups, the bacteria had disappeared naturally in 67% of the gerbils and mucosal damage was mitigated in the Hp + rebamipide group at four weeks after the inoculation. Collectively, rebamipide might play a role in inhibiting the level of H. pylori colonization and gastric lesion formation in Mongolian gerbils.
定植于胃黏膜的幽门螺杆菌在胃黏膜病变中起重要致病作用。我们之前报道过乙醇预处理会促进幽门螺杆菌相关病变的扩展。本研究旨在检测黏膜保护剂瑞巴派特对幽门螺杆菌相关损伤的影响。雄性蒙古沙鼠经口接种幽门螺杆菌；在接种前30分钟，给这些沙鼠经口给予40%乙醇（Hp组）。对照组给予40%乙醇和培养基（对照组）。Hp组和对照组中的一些沙鼠喂食含瑞巴派特的饮食，其余沙鼠给予实验室普通饲料。通过定量细菌培养和组织学检查评估幽门螺杆菌感染情况。尽管在Hp组中持续检测到幽门螺杆菌且观察到明显的黏膜白细胞浸润，但在接种后四周，67%的沙鼠体内细菌自然消失，且Hp + 瑞巴派特组的黏膜损伤得到减轻。总体而言，瑞巴派特可能在抑制蒙古沙鼠体内幽门螺杆菌定植水平和胃病变形成方面发挥作用。
