Mauricio D, Mandrup-Poulsen T
Endocrine Unit, Consorci Hospitalari Parc Taulí, Sabadell, Spain.
Diabetes. 1998 Oct;47(10):1537-43. doi: 10.2337/diabetes.47.10.1537.
In type 1 diabetes, an immune-mediated process leads to the destruction of pancreatic beta-cells. In the last decade, considerable progress has been made in understanding the cellular and biochemical pathogenic processes of the disease. However, more needs to be learned about the immune mechanisms leading to the development of autoreactive immune cells and the molecular mechanisms of beta-cell death. The study of apoptosis of autoreactive lymphocytes as well as apoptosis of beta-cells may give answers to many still unsolved questions. This review focuses on the possible role of apoptosis both in the regulation of immune mechanisms involved in the pathogenesis of type 1 diabetes and as a way for beta-cells to die. The advancement in the knowledge of the possible role of apoptosis and its regulation in the pathogenesis of type 1 diabetes may provide new therapeutic tools for the prevention of the disease.
在1型糖尿病中，免疫介导的过程导致胰腺β细胞的破坏。在过去十年中，在了解该疾病的细胞和生化致病过程方面取得了相当大的进展。然而，关于导致自身反应性免疫细胞发展的免疫机制以及β细胞死亡的分子机制，仍有更多需要了解的地方。对自身反应性淋巴细胞凋亡以及β细胞凋亡的研究可能会为许多尚未解决的问题提供答案。本综述重点关注凋亡在1型糖尿病发病机制中所涉及的免疫机制调节中的可能作用，以及作为β细胞死亡的一种方式。对凋亡在1型糖尿病发病机制中的可能作用及其调节的认识进展，可能为该疾病的预防提供新的治疗工具。
