Thomson N C
University of Glasgow, Glasgow, United Kingdom.
Can Respir J. 1998 Jul-Aug;5 Suppl A:60A-3A.
Theophylline acts as a bronchodilator and has bronchoprotective activity in asthma. The importance of the anti-inflammatory properties of theophylline to its clinical efficacy remains uncertain. Theophylline has a place in management as an additional long term control medication for patients whose asthma is not controlled by an inhaled, short acting beta-agonists and inhaled steroid. For most patients an inhaled, long acting beta-agonist should be tried before oral theophylline. The relative efficacy and side effect profile of oral theophylline versus oral leukotriene modulators as an 'add on' therapy remain to be established.
茶碱作为一种支气管扩张剂，在哮喘中具有支气管保护活性。茶碱的抗炎特性对其临床疗效的重要性仍不确定。对于哮喘未被吸入短效β受体激动剂和吸入性类固醇控制的患者，茶碱作为一种额外的长期控制药物在治疗中占有一席之地。对于大多数患者，在使用口服茶碱之前应先尝试吸入长效β受体激动剂。口服茶碱与口服白三烯调节剂作为“附加”疗法的相对疗效和副作用情况仍有待确定。
