Hirose Y, Kimura H, Kitahara H, Tanaka K, Wada T, Oshita S
Department of Anesthesiology, Tokushima University School of Medicine.
Masui. 1998 Aug;47(8):918-24.
Eighteen dogs under halothane or isoflurane anesthesia were subjected for a study in skin blood flow of the forearm under acute isovolemic hemodilution. Hematocrit was intentionally reduced to about 50% of baseline in ten minutes and hematocrit changes were induced by exchange of blood with hydroxyethyl starch. The skin blood flow increase response, measured by laser Doppler flowmetry, to hemodilution was abolished after inhibition of endogenous nitric oxide synthesis by N omega-nitro-L-arginine methyl ester. Skin blood flow responses to hemodilution and N omega-nitro-L-arginine methyl ester were different between halothane group and isoflurane group. Nitric oxide may have an important part to play in vasodilation during acute isovolemic hemodilution, and it may be affected differently by halothane and isoflurane.
18只接受氟烷或异氟烷麻醉的狗被用于一项关于急性等容血液稀释状态下前臂皮肤血流的研究。在10分钟内将血细胞比容有意降至基线的约50%，通过用羟乙基淀粉进行血液交换来诱导血细胞比容变化。在用N-ω-硝基-L-精氨酸甲酯抑制内源性一氧化氮合成后，通过激光多普勒血流仪测量的对血液稀释的皮肤血流增加反应消失。氟烷组和异氟烷组对血液稀释和N-ω-硝基-L-精氨酸甲酯的皮肤血流反应不同。一氧化氮可能在急性等容血液稀释期间的血管舒张中起重要作用，并且它可能受到氟烷和异氟烷的不同影响。
