Miyake K, Masuda K, Shirato S, Oshika T, Eguchi K, Hoshi H, Majima Y, Kimura W, Hayashi F
Miyake Eye Hospital, Aichi-ken, Japan.
Nippon Ganka Gakkai Zasshi. 1998 Aug;102(8):522-30.
Using eyes undergoing phacoemulsification followed by implantation of a foldable acrylic intraocular lens (IOL) designed for small-incision cataract surgery, a multi-center study was performed to compare a non-steroidal ophthalmic solution (0.1% diclofenac) to a steroidal ophthalmic solution (0.1% fluorometholone) in preventing cystoid macular edema (CME) and inducing disruption of the blood-aqueous barrier determined by laser flare cellmetry. The incidence of CME, noted in 3 out of 53 eyes (5.7%) receiving diclofenac and in 29 out of 53 eyes (54.7%) receiving fluorometholone, was significantly lower in the diclofenac group. The flare in the anterior chamber was also significantly lower in the diclofenac group; when compared between eyes with and without CME, the amount of flare was significantly higher in the former group. These findings suggest that diclofenac effectively prevents CME following cataract surgery and that CME is closely related to the breakdown of the blood-aqueous barrier.
采用接受超声乳化白内障吸除术并植入专为小切口白内障手术设计的可折叠丙烯酸人工晶状体（IOL）的眼睛，进行了一项多中心研究，以比较一种非甾体类眼用溶液（0.1%双氯芬酸）和一种甾体类眼用溶液（0.1%氟米龙）在预防黄斑囊样水肿（CME）以及通过激光散射细胞测量法诱导血-房水屏障破坏方面的效果。CME的发生率在接受双氯芬酸的53只眼中有3只（5.7%）出现，在接受氟米龙的53只眼中有29只（54.7%）出现，双氯芬酸组的发生率显著更低。双氯芬酸组前房的散射光也显著更低；在有和没有CME的眼睛之间进行比较时，前一组的散射光量显著更高。这些发现表明双氯芬酸能有效预防白内障手术后的CME，并且CME与血-房水屏障的破坏密切相关。
