Gupta M, Mazumder U K, Das S
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
Indian J Exp Biol. 1998 Feb;36(2):171-4.
Effect of acute multiple (20, 40 and 80 mg/kg body wt, i.p.) doses of C. colebrookianum leaf extract on behaviour, convulsion, analgesia and sedative-hypnosis was studied in mice. A marginal reduction of awareness and motor activity was observed in low (20 mg) and moderate (40 mg) dose level of extract. However, 80 mg dose caused marked inhibition of awareness and motor activity. Grip strength and stereotypy was observed in all the dose levels. The extract alone did not show loss of righting reflex but it prolonged the effect of meprobamate, diazepam, chlorpromazine and pentobarbitone significantly in a dose dependent manner. The extract neither produced analgesia alone nor it altered analgesic effect of morphine and pethidine. Pretreatment of the extract caused significant protection of strychnine and leptazol induced convulsion and mortality. The results suggest a mild (or dose dependent) CNS depressant action of leaf extract of C. colebrookianum in mice.
研究了急性多次（20、40和80毫克/千克体重，腹腔注射）剂量的柯氏金盏苣苔叶提取物对小鼠行为、惊厥、镇痛和镇静催眠的影响。在低剂量（20毫克）和中等剂量（40毫克）的提取物水平下，观察到意识和运动活动略有降低。然而，80毫克剂量导致意识和运动活动明显受到抑制。在所有剂量水平下均观察到握力和刻板行为。提取物单独使用时未显示翻正反射丧失，但它以剂量依赖的方式显著延长了眠尔通、地西泮、氯丙嗪和戊巴比妥的作用。提取物单独使用时既不产生镇痛作用，也不改变吗啡和哌替啶的镇痛效果。提取物预处理可显著保护士的宁和戊四氮诱导的惊厥和死亡。结果表明，柯氏金盏苣苔叶提取物在小鼠中具有轻度（或剂量依赖性）的中枢神经系统抑制作用。
