Gautam N, Downes G B, Yan K, Kisselev O
Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Cell Signal. 1998 Jul;10(7):447-55. doi: 10.1016/s0898-6568(98)00006-0.
The vast majority of signalling pathways in mammalian cells are mediated by heterotrimeric (alpha betagamma) G proteins. Reviewed here is regulation of signal transduction by the betagamma complex at different protein interfaces: subunit-subunit, receptor-G protein and G protein-effector. The role of diverse beta and gamma subunit types in achieving specificity in signalling and potentially unidentified functions for these subunits also are discussed.
哺乳动物细胞中的绝大多数信号通路是由异源三聚体（αβγ）G蛋白介导的。本文综述了βγ复合物在不同蛋白质界面（亚基-亚基、受体-G蛋白和G蛋白-效应器）对信号转导的调节作用。还讨论了不同β和γ亚基类型在信号传导特异性方面的作用以及这些亚基潜在的未知功能。
