The role of the beta-noradrenergic system in cholecystokinin-tetrapeptide-induced panic symptoms.
作者信息
Le Mellédo J M, Bradwejn J, Koszycki D, Bichet D G, Bellavance F
机构信息
Clarke Institute of Psychiatry, University of Toronto, Ontario, Canada.
出版信息
Biol Psychiatry. 1998 Sep 1;44(5):364-6. doi: 10.1016/s0006-3223(97)00536-2.
BACKGROUND
The authors determined whether effective beta-adrenergic blockade could attenuate the panicogenic effects of cholecystokinin-tetrapeptide (CCK-4) in healthy volunteers.
METHODS
Subjects were randomly assigned to either a propranolol (n = 14) or placebo (n = 16) infusion. Ten minutes after completion of the infusion subjects received a bolus injection of CCK-4 (50 micrograms).
RESULTS
Acute pretreatment with propranolol was more effective than placebo in decreasing behavioral and cardiovascular sensitivity.
CONCLUSIONS
These preliminary results suggest that the panicogenic effects of CCK-4 are mediated, in part, through the beta-adrenergic system.
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