Nakamura A, Taniguchi K, Tsurubuchi K, O'Hara K, Sawai T
Division of Microbial Chemistry, Faculty of Pharmaceutical Sciences, Chiba University.
Jpn J Antibiot. 1998 Jul;51(7):494-500.
Minimum inhibitory concentrations (MICs) of erythromycin, clarithromycin, roxithromycin, oleandomycin, triacetyloleandomycin, azithromycin, josamycin and midecamycin were investigated using 200 strains of methicillin-resistant Staphylococcus aureus (MRSA) clinically isolated in Japan during 1996. The results show that the MRSAs could be classified into five groups according to MIC patterns to various macrolides and that more than 88% of the strains used were highly-resistant to all macrolides tested. It was found that 9.0% of the strains examined showed a unique MIC pattern different to that of macrolide-lincosamide-streptogramin B antibiotic resistance type. This group was found to be highly resistant to 14-membered but susceptible to 16-membered macrolides. The resistance induction by erythromycin or oleandomycin was observed to increase for clarithromycin and roxithromycin resistances in a part of strains used. On the other hand, for azithromycin, such induction was not observed.
对1996年期间在日本临床分离出的200株耐甲氧西林金黄色葡萄球菌（MRSA）进行了红霉素、克拉霉素、罗红霉素、竹桃霉素、三乙酰竹桃霉素、阿奇霉素、交沙霉素和麦迪霉素的最低抑菌浓度（MIC）研究。结果表明，根据对各种大环内酯类药物的MIC模式，MRSA可分为五组，且超过88%的受试菌株对所有测试大环内酯类药物高度耐药。发现9.0%的受试菌株呈现出与大环内酯-林可酰胺-链阳菌素B抗生素耐药类型不同的独特MIC模式。该组对14元大环内酯类药物高度耐药，但对16元大环内酯类药物敏感。在部分受试菌株中，观察到红霉素或竹桃霉素诱导的耐药性会增加对克拉霉素和罗红霉素的耐药性。另一方面，对于阿奇霉素，未观察到这种诱导现象。
