铟-111 卡普单抗显像的双同位素方案
Dual-isotope protocol for indium-111 capromab pendetide monoclonal antibody imaging.
作者信息
Kelty N L, Holder L E, Khan S H
机构信息
Department of Radiology, University of Maryland Medical Center, Baltimore 21201-1595, USA.
出版信息
J Nucl Med Technol. 1998 Sep;26(3):174-7.
OBJECTIVE
A dual-isotope imaging protocol using 99mTc-labeled red blood cells with 111In capromab pendetide monoclonal antibody imaging for detective and localizing nodal metastasis in prostate cancer is described.
METHODS
This protocol involves a single SPECT acquisition that is less time consuming and more comfortable for the patient than the currently recommended method, which requires two separate SPECT acquisitions performed on different days.
RESULTS
Forty patients were studied with the dual-isotope protocol. Preliminary data suggest increased accuracy compared with the single-isotope technique.
CONCLUSION
The dual-isotope technique assures the precise image registration needed for accurate comparison of blood pool and pelvic lymph node activity that is required for confident and accurate image interpretation.
目的
描述一种双同位素成像方案，该方案使用99mTc标记的红细胞与111In卡普单抗戊肽单克隆抗体成像来检测和定位前列腺癌的淋巴结转移。
方法
该方案涉及单次SPECT采集，与目前推荐的方法相比，这种方法耗时更少，对患者来说也更舒适，目前推荐的方法需要在不同日期进行两次单独的SPECT采集。
结果
40例患者采用双同位素方案进行研究。初步数据表明，与单同位素技术相比，准确性有所提高。
结论
双同位素技术可确保精确的图像配准，这是准确比较血池和盆腔淋巴结活性所必需的，而这对于可靠且准确的图像解读是必不可少的。
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