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商业制备的放射性药物单剂量中使用和未使用一次性防护插入物的铅制单剂量容器的血液污染发生率。

The incidence of blood contamination of lead unit dose containers with and without single-use protective inserts used with commercially prepared radiopharmaceutical unit doses.

作者信息

Pickett M W, Kosegi J E, Thomas K S, Waterstram-Rich K M

机构信息

Department of Nuclear Medicine Technology, College of Health Related Professions, University of Arkansas for Medical Sciences, Little Rock 72205-7199, USA.

出版信息

J Nucl Med Technol. 1998 Sep;26(3):200-3.

PMID:9755441
Abstract

OBJECTIVE

This investigation evaluated the effectiveness of disposable plastic inserts in radiopharmaceutical unit dose lead containers (pigs) in preventing the distribution of doses in blood-contaminated containers. Technologists commonly dispose of the syringes by placing them into the lead pigs, leaving the needles uncapped. This process raises the question of unsuspected blood contamination of these pigs. Consequently, the distribution of commercially prepared radiopharmaceutical doses in reusable lead pigs may result in radiopharmaceutical doses being distributed in containers that are contaminated with blood.

METHODS

Using a simple chemical wipe test designed to determine the presence or absence of blood contamination, 618 pigs from commercial radiopharmacies throughout the U.S. were tested for contamination. The inside of the pigs and inserts, if present, were wiped before and after dose administration. Of the pigs tested, 292 came from radiopharmacies that used a protective, disposable plastic insert inside the pig, and 326 came from radiopharmacies that did not use an insert.

RESULTS

Of those pigs without the protective disposable inserts, 39.3% arrived in the nuclear medicine department in pigs contaminated with blood. Of those pigs with inserts, 1% arrived with blood-contaminated inserts. After dose administration, 46.3% of the pigs without inserts were contaminated with blood and 3% of the protective inserts were contaminated.

CONCLUSION

The proper use of disposable plastic inserts reduces the possibility of distributing radiopharmaceutical unit doses in containers contaminated with blood.

摘要

目的

本研究评估了放射性药物单剂量铅罐(铅猪)中一次性塑料内衬在防止血液污染容器中剂量分布方面的有效性。技术人员通常将注射器放入铅猪中处理,针头不盖帽。这个过程引发了这些铅猪是否存在未被察觉的血液污染的问题。因此,在可重复使用的铅猪中分发商业制备的放射性药物剂量可能会导致放射性药物剂量被分发到被血液污染的容器中。

方法

使用一种简单的化学擦拭测试来确定是否存在血液污染,对美国各地商业放射性药房的618个铅猪进行了污染测试。在给药前后擦拭铅猪内部以及(如果有的话)内衬内部。在测试的铅猪中,292个来自在铅猪内部使用了保护性一次性塑料内衬的放射性药房,326个来自未使用内衬的放射性药房。

结果

在那些没有保护性一次性内衬的铅猪中,39.3%到达核医学科时已被血液污染。在那些有内衬的铅猪中,1%到达时内衬被血液污染。给药后,46.3%没有内衬的铅猪被血液污染,3%的保护性内衬被污染。

结论

正确使用一次性塑料内衬可降低在被血液污染的容器中分发放射性药物单剂量的可能性。

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