Kanamura H Y, Dias L C, da Silva R M, Glasser C M, Patucci R M, Vellosa S A, Antunes J L
Faculdade de Ciências Farmacêuticas, Universidade de S. Paulo, Brazil.
Rev Inst Med Trop Sao Paulo. 1998 Mar-Apr;40(2):85-91. doi: 10.1590/s0036-46651998000200004.
The diagnostic potential of circulating IgM and IgA antibodies against Schistosoma mansoni gut-associated antigens detected by the immunofluorescence test (IFT) on adult worm paraffin sections was evaluated comparatively to the fecal parasitological method, for epidemiological purposes in low endemic areas for schistosomiasis. Blood samples were collected on filter paper from two groups of schoolchildren living in two different localities of the municipality of Itariri (São Paulo, Brazil) with different histories and prevalences of schistosomiasis. The parasitological and serological data were compared to those obtained for another group of schoolchildren from a non-endemic area for schistosomiasis. The results showed poor sensitivity of the parasitological method in detecting individuals with low worm burden and indicate the potential of the serological method as an important tool to be incorporated into schistosomiasis control and vigilance programs for determining the real situation of schistosomiasis in low endemic areas.
为了在血吸虫病低流行地区开展流行病学研究，我们比较了免疫荧光试验（IFT）检测循环中抗曼氏血吸虫肠道相关抗原的IgM和IgA抗体的诊断潜力与粪便寄生虫学方法。从居住在伊塔里里市（巴西圣保罗）两个不同地区、具有不同血吸虫病病史和流行率的两组学童中采集滤纸血样。将寄生虫学和血清学数据与另一组来自非血吸虫病流行地区的学童的数据进行比较。结果表明，寄生虫学方法在检测低虫负荷个体时敏感性较差，这表明血清学方法有潜力成为血吸虫病控制和监测项目中的一项重要工具，用于确定低流行地区血吸虫病的实际情况。
