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[Ollier病中的软骨肉瘤。附2例报告及文献复习]

[Chondrosarcoma in Ollier's disease. Apropos of 2 cases and review of the literature].

作者信息

Hasbini A, Lartigau E, Le Péchoux C, Acharki A, Vanel D, Genin J, Le Cesne A

机构信息

Service de radiothérapie, institut Gustave-Roussy, Villejuif, France.

出版信息

Cancer Radiother. 1998 Jul-Aug;2(4):387-91. doi: 10.1016/s1278-3218(98)80351-x.

Abstract

Ollier's disease is a rate affliction (not more than approximately 100 cases have been reported over a 30-year period) characterized by bone dysplasia in which evolution to degenerative neoplasia has been described. Diagnosis of chondrosarcoma is delicate in these cases. It is a kind of slowly evolving low grade malignant tumor. Surgery is the primary treatment course, and can lead to remission. Prognosis, depending on the number and dimension of the lesions, their localization and metastasis prevention, is usually good, but relapses are relatively frequent: 25 to 50%. In case of relapse, radiotherapy and chemotherapy were tested but their efficacy is limited. We report here two clinical cases and discuss literature data.

摘要

骨软骨瘤病是一种罕见疾病(30年间报告的病例不超过约100例),其特征为骨发育异常,且已报道有演变为退行性肿瘤的情况。在这些病例中,软骨肉瘤的诊断较为棘手。它是一种缓慢进展的低级别恶性肿瘤。手术是主要的治疗方法,可导致病情缓解。预后通常较好,取决于病变的数量、大小、位置以及预防转移情况,但复发相对频繁,复发率为25%至50%。复发时曾尝试放疗和化疗,但其疗效有限。我们在此报告两例临床病例并讨论文献数据。

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