[突尼斯的皮肤淋巴瘤：临床概况与治疗结果]
[Cutaneous lymphoma in Tunisia: clinical profile and therapeutic results].
作者信息
Maalej M, Frikha H, Daoud J, Sellami D, Ben Romdhane K, Kamoun M R, Souissi R, Ben Osmen A, Zahaf A, Nouira R, Bouaouina N, Ben Abdallah M
机构信息
Institut Salah Azaiz, Tunis, Tunisie.
出版信息
Cancer Radiother. 1998 Jul-Aug;2(4):404-7. doi: 10.1016/S1278-3218(98)80353-3.
PURPOSE
The aim of this retrospective study was to investigate therapeutic result of cutaneous lymphoma in Tunisia.
PATIENTS AND METHODS
Between January 1969 and June 1994, 100 patients with cutaneous lymphoma were referred either to Salah Azaiz Institute or the other University Hospitals of Tunisia. Fifty-one patients had epidermotropic lymphoma and 49 non-epidermotropic lesions. Eighty-seven patients received complete treatment. Puvatherapy and other local dermatologic treatments were used for early stage mycosis fungoïdes. Thirty-two patients benefited from radiotherapy, with curative dose in 28 cases. Chemotherapy including anthracyclin agents was used for high grade lymphoma. Thirteen patients had association of radiotherapy and chemotherapy.
RESULTS
Five-year survival rates were 50% for patients with epidermotropic lesions and 56% for patients with non-epidermotropic cutaneous lymphoma. Statistical study has not identified any significant prognosis factor.
CONCLUSION
Radiotherapy and chemotherapy are both effective. Treatment should depend on stage and histologic type.
目的
这项回顾性研究的目的是调查突尼斯皮肤淋巴瘤的治疗效果。
患者与方法
1969年1月至1994年6月期间，100例皮肤淋巴瘤患者被转诊至突尼斯的萨拉赫·阿扎伊兹研究所或其他大学医院。51例患者患有亲表皮性淋巴瘤，49例有非亲表皮性病变。87例患者接受了完整治疗。补骨脂素疗法和其他局部皮肤科治疗用于早期蕈样真菌病。32例患者接受了放射治疗，其中28例采用了根治性剂量。包括蒽环类药物在内的化疗用于高级别淋巴瘤。13例患者接受了放疗和化疗联合治疗。
结果
亲表皮性病变患者的5年生存率为50%，非亲表皮性皮肤淋巴瘤患者为56%。统计学研究未发现任何显著的预后因素。
结论
放疗和化疗均有效。治疗应取决于分期和组织学类型。
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