Mukherjee B, Anbazhagan S, Roy A, Ghosh R, Chatterjee M
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
Biomed Pharmacother. 1998;52(2):89-95. doi: 10.1016/S0753-3322(98)80008-5.
Levels of blood glucose, lipid peroxidation, glutathione (GSH), glutathione peroxidase (GPx), glutathione S-transferase (GST) activities and blood selenium levels were determined in streptozotocin (STZ)-induced diabetic mice. The effect of oral administration of sodium selenite was studied on the above parameters. Diabetes caused hyperglycemia (2.8-fold increase) with a significant increase in the malondialdehyde levels (89% in liver and 83% in blood) and GST activity (55%) and marked decreases in GSH levels (approximately 73% in blood and 79% in liver) in the 5th week after STZ treatment as compared to normal control animals. Treatment of STZ-induced diabetic mice with sodium selenite changed these parameters to near control values in almost all cases. These results suggest that selenium plays a role in reducing the oxidative stress associated with diabetes.
测定链脲佐菌素（STZ）诱导的糖尿病小鼠的血糖水平、脂质过氧化、谷胱甘肽（GSH）、谷胱甘肽过氧化物酶（GPx）、谷胱甘肽S-转移酶（GST）活性及血硒水平。研究了口服亚硒酸钠对上述参数的影响。与正常对照动物相比，糖尿病导致血糖升高（增加2.8倍），丙二醛水平显著升高（肝脏中升高89%，血液中升高83%），GST活性升高（55%），而在STZ治疗后第5周，GSH水平显著降低（血液中约降低73%，肝脏中约降低79%）。用亚硒酸钠治疗STZ诱导的糖尿病小鼠，几乎在所有情况下这些参数都恢复到接近对照值。这些结果表明，硒在减轻与糖尿病相关的氧化应激中发挥作用。
