Franceschini R, Robaudo C, Corsini G, Cataldi A, Bruno E, Russo R, Rolandi E, Barreca T
Department of Internal Medicine, University of Genoa, Italy.
Biomed Pharmacother. 1998;52(5):208-13. doi: 10.1016/S0753-3322(98)80018-8.
In order to evaluate somatostatin (SRIH) secretion in uremia, plasma SRIH concentrations were determined in basal conditions and after an oral glucose tolerance test (OGTT) in 14 non-dialysed patients with chronic renal failure (CRF), seven of whom had normal glucose tolerance (NGT) and seven impaired glucose tolerance (IGT). Plasma insulin, C-peptide and glucagon and blood glucose concentrations were also evaluated. The results were compared with those obtained in a group of age- and sex-matched normal subjects. In CRF patients, plasma SRIH fasting values (8.6 +/- 0.6 and 7.8 +/- 0.6 pmol/L in NGT and IGT patients, respectively) were comparable to those recorded in controls (7.7 +/- 0.5 pmol/L). SRIH response to OGTT, evaluated as area under curves (AUC) above basal, was similar in both groups of CRF patients (412.9 +/- 84.5 and 415.6 +/- 51.9 pmol/L per min), and significantly lower than in controls (660.1 +/- 58.5 pmol/L per min). Data indicate that chronic uremia induces a loss of SRIH secretory cell responsiveness to glucose. A possible effect of impaired SRIH secretion on glucose metabolism in CRF is discussed.
为了评估尿毒症患者生长抑素（SRIH）的分泌情况，我们测定了14例未接受透析的慢性肾衰竭（CRF）患者在基础状态及口服葡萄糖耐量试验（OGTT）后的血浆SRIH浓度，其中7例患者糖耐量正常（NGT），7例患者糖耐量受损（IGT）。同时还评估了血浆胰岛素、C肽、胰高血糖素以及血糖浓度。将结果与一组年龄和性别匹配的正常受试者所得结果进行比较。在CRF患者中，血浆SRIH空腹值（NGT组和IGT组患者分别为8.6±0.6和7.8±0.6 pmol/L）与对照组记录值（7.7±0.5 pmol/L）相当。以基础值以上曲线下面积（AUC）评估的CRF患者两组对OGTT的SRIH反应相似（分别为412.9±84.5和415.6±51.9 pmol/L每分钟），且显著低于对照组（660.1±58.5 pmol/L每分钟）。数据表明慢性尿毒症导致SRIH分泌细胞对葡萄糖的反应性丧失。本文讨论了CRF中SRIH分泌受损对葡萄糖代谢的可能影响。
