丙磺舒对新型碳青霉烯类药物DA - 1131在犬体内肾脏排泄机制无影响。

No effect of probenecid on the renal excretion mechanism of a new carbapenem, DA-1131, in dogs.

作者信息

Kim S H, Kim W B, Lee M G

机构信息

College of Pharmacy, Seoul National University, South Korea.

出版信息

Res Commun Mol Pathol Pharmacol. 1998 Jul;101(1):85-92.

PMID:9755846

Abstract

The effect of probenecid, an anion transport inhibitor, on the renal excretion mechanism of a new anionic carbapenem, DA-1131, was investigated after 1-min intravenous infusion of DA-1131, 10 mg/kg, with or without probenecid, 50 mg/kg, to dogs. The renal clearance (CL(R)) of DA-1131 in dogs without probenecid (3.18+/-0.247 ml/min/kg) was considerably smaller than the reported creatinine clearance (CL(CR)) in dogs, 6.13 ml/min/kg, indicating that renal tubular reabsorption of the drug was observed in dogs. However, the CLR of DA-1131 was not significantly different (3.18+/-0.247 versus 3.29+/-0.698 ml/min/kg) by treatment with probenecid indicating that the tubular reabsorption of DA-1131 was not inhibited by probenecid.

摘要

在给犬静脉注射10mg/kg的新型阴离子碳青霉烯类药物DA - 1131（注射时间为1分钟），同时或不同时注射50mg/kg丙磺舒的情况下，研究了阴离子转运抑制剂丙磺舒对DA - 1131肾脏排泄机制的影响。未注射丙磺舒的犬体内DA - 1131的肾清除率（CL(R)）（3.18±0.247ml/min/kg）显著低于报道的犬肌酐清除率（CL(CR)）（6.13ml/min/kg），这表明在犬体内观察到了该药物的肾小管重吸收。然而，注射丙磺舒后DA - 1131的CLR并无显著差异（3.18±0.247对比3.29±0.698ml/min/kg），这表明丙磺舒并未抑制DA - 1131的肾小管重吸收。