Franck J, Lindholm S, Raaschou P
Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
Alcohol Clin Exp Res. 1998 Sep;22(6):1185-9.
The acute effect of opioid antagonists on volitional ethanol intake was studied in unselected Sprague-Dawley rats using a two-bottle, free-choice model. The total daily intake of ethanol during saline treatment was 1.79 +/- 0.4 g/kg/day (n = 136). The rats were deprived of fluids for the last 4 hr of the light period. Saline or drug was given intraperitoneally 20 to 30 min before the onset of dark, and the ethanol and water intakes were measured during the following hour. The ethanol intake during this hour was 0.75 +/- 0.06 g/kg (n = 136). Naltrexone significantly reduced ethanol intake. There was also a significant reduction in ethanol intake following administration of ICI-174,864. Naloxonazine and naloxone methiodide lacked effect. None of the treatments had any effect on the water or food intake. The results suggest that central delta-opioid receptors modulate volitional ethanol intake in the rat.
使用双瓶自由选择模型，在未筛选的斯普拉格 - 道利大鼠中研究了阿片类拮抗剂对自愿乙醇摄入量的急性影响。生理盐水处理期间乙醇的每日总摄入量为1.79±0.4克/千克/天（n = 136）。在光照期的最后4小时剥夺大鼠的水分。在黑暗开始前20至30分钟腹腔注射生理盐水或药物，并在接下来的一小时内测量乙醇和水的摄入量。这一小时内乙醇摄入量为0.75±0.06克/千克（n = 136）。纳曲酮显著降低了乙醇摄入量。给予ICI - 174,864后乙醇摄入量也显著降低。纳洛嗪和甲硫碘化纳洛酮没有效果。所有处理对水或食物摄入量均无影响。结果表明，中枢δ - 阿片受体调节大鼠的自愿乙醇摄入量。
