胶质细胞系源性神经营养因子可保护C57BL/6小鼠免受1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱导的神经毒性。
Glial cell line-derived neurotrophic factor protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in C57BL/6 mice.
作者信息
Cheng F C, Ni D R, Wu M C, Kuo J S, Chia L G
机构信息
Department of Medical Research, Taichung Veterans General Hospital, Taiwan.
出版信息
Neurosci Lett. 1998 Aug 14;252(2):87-90. doi: 10.1016/s0304-3940(98)00554-0.
To mimic chronic exposure to neurotoxins in inducing dopaminergic cell damage, multiple doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were injected in C57BL/6 mice. Effects of pre- and post-treatment with the glial cell line-derived neurotrophic factor (GDNF) by injections into the striatum were investigated. GDNF exerts protective and reverse effects on the dopaminergic damage, supporting the potential application of GDNF in prevention and treatment of Parkinson's disease.
为模拟长期暴露于神经毒素诱导多巴胺能细胞损伤的情况，向C57BL/6小鼠注射多剂量的1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）。研究了通过向纹状体注射胶质细胞源性神经营养因子（GDNF）进行预处理和后处理的效果。GDNF对多巴胺能损伤具有保护和逆转作用，支持GDNF在帕金森病预防和治疗中的潜在应用。
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