Johnson C D, Gilbey M P
Autonomic Neuroscience Institute, Department of Physiology, Royal Free Hospital School of Medicine, London NW3 2PF, United Kingdom.
Am J Physiol. 1998 Oct;275(4):R942-9. doi: 10.1152/ajpregu.1998.275.4.R942.
Activity was recorded from postganglionic sympathetic neurons (PSNs) innervating either the caudal ventral artery (CVA) or a lateral vein (LV) of the tail circulation of anesthetized rats. The study sought to determine whether sympathetic activity directed at the CVA and LV was influenced by cardiovascular mechanoreceptor afferents and whether this effect was differential. Cardiac rhythmicity was not a robust component of either CVA PSN activity or LV PSN activity. Stimulation of an aortic nerve with short trains was followed by a decreased probability of discharge in both CVA and LV PSNs that was followed by a series of peaks that showed a constant periodicity that was not significantly different from that revealed by autocorrelogram analysis over the same data set. The latter dominant periodicity is referred to in this and related previous publications as the T rhythm. Furthermore, blood volume expansion and long-train aortic nerve stimulation produced a significant decrease in the frequency of the T rhythm. It is concluded that the CVA and LV sympathetic activity can be influenced by inputs from cardiovascular mechanoreceptors and that this effect is mediated in part by a modulation of the T rhythm.
记录了支配麻醉大鼠尾部循环的尾腹侧动脉（CVA）或侧静脉（LV）的节后交感神经元（PSN）的活动。该研究旨在确定指向CVA和LV的交感神经活动是否受心血管机械感受器传入神经的影响，以及这种影响是否存在差异。心脏节律性在CVA PSN活动或LV PSN活动中均不是一个强大的组成部分。用短串刺激主动脉神经后，CVA和LV PSN的放电概率均降低，随后出现一系列峰值，这些峰值显示出恒定的周期性，与对同一数据集进行自相关图分析所揭示的周期性无显著差异。在本出版物及相关先前出版物中，后一种主导周期性被称为T节律。此外，血容量扩张和长时间刺激主动脉神经会使T节律的频率显著降低。结论是，CVA和LV交感神经活动可受心血管机械感受器输入的影响，且这种影响部分是通过对T节律的调节来介导的。
