The 5-HT1A agonist 8-OH-DPAT increases the number of spike-wave discharges in a genetic rat model of absence epilepsy.

作者信息

Gerber K, Filakovszky J, Halasz P, Bagdy G

机构信息

Laboratory of Neurochemistry and Experimental Medicine, National Institute of Psychiatry and Neurology, Hüvösvölgyi út 116, 1021, Budapest, Hungary.

出版信息

Brain Res. 1998 Oct 5;807(1-2):243-5. doi: 10.1016/s0006-8993(98)00801-4.

The effects of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) on the epileptiform activity has been investigated in adult WAG/RIJ rats. Either intraperitoneal (0.1-0.5 mg/kg) or intracerebroventricular (2-20 microg/rat) administration of 8-OH-DPAT caused marked, dose-dependent increases in the number and mean cumulative duration of spike-wave discharges. These effects were attenuated by NAN-190, a 5-HT1A receptor antagonist. These data indicate that serotonergic system regulates the epileptiform activity in this genetic model of human absence epilepsy.