Wong L K, Biemann K
Clin Toxicol. 1976;9(4):583-91. doi: 10.3109/15563657608988160.
The results of the animal experiment demonstrate that oxidative hydroxylation is the major mode of metabolism of phencyclidine. It is evident that this process takes place in all three rings of the molecule. Hydroxylation of the piperidyl moiety probably also accounts for the formation of the N-dealkylated metabolites. Metabolism of phencyclidine in humans appears, at least in part, to be similar to that in the rat. Hydroxylation is still the principal mode in the case of humans though of a lesser extent. Metabolites hydroxylated in the phenyl moiety as well as dihydroxy derivatives of phencyclidine have so far not been observed in humans. Furthermore, most of the monohydroxy metabolites exist as conjugates in the human urine. It should also be pointed out that no metabolites have yet been detected in human blood samples.
动物实验结果表明，氧化羟基化是苯环己哌啶的主要代谢方式。显然，该过程发生在分子的所有三个环中。哌啶基部分的羟基化可能也参与了N-脱烷基代谢物的形成。苯环己哌啶在人体内的代谢至少部分与大鼠相似。羟基化仍是人类的主要代谢方式，不过程度较低。在人体内尚未观察到苯环部分羟基化的代谢物以及苯环己哌啶的二羟基衍生物。此外，大多数单羟基代谢物在人类尿液中以缀合物形式存在。还应指出的是，在人类血液样本中尚未检测到任何代谢物。
