Grayson M H, Bochner B S
Department of Medicine, Mount Sinai School of Medicine, USA.
Mt Sinai J Med. 1998 Sep;65(4):246-56.
This review delineates the currently accepted, multifaceted approach to the care of an asthmatic patient. Therapy is based on our improved understanding of the pathophysiology of this complex disease, in which IgE and mediators derived from many cells contribute to airway inflammation. The latest trends in therapy involve the institution of anti-inflammatory medications relatively early in disease. With the recent availability of a novel class of therapies, the leukotriene antagonists, and other therapies based on antagonism of adhesion molecules, cytokines, chemokines, or IgE itself, the future may provide additional alternatives for the physician treating patients with asthma.
本综述阐述了目前公认的、多方面的哮喘患者护理方法。治疗基于我们对这种复杂疾病病理生理学的深入理解，在该疾病中，IgE和源自多种细胞的介质会导致气道炎症。治疗的最新趋势是在疾病早期就使用抗炎药物。随着一类新型疗法（白三烯拮抗剂）以及其他基于拮抗黏附分子、细胞因子、趋化因子或IgE本身的疗法的出现，未来可能会为治疗哮喘患者的医生提供更多选择。
