Wolf R E, Adamashvili I M, Gelder F B, Hall V C, Fraser P A, McDonald J C
Department of Medicine, Louisiana State University Medical Center, Shreveport 71130-3932, USA.
Hum Immunol. 1998 Oct;59(10):644-9. doi: 10.1016/s0198-8859(98)00071-8.
To study serum levels of Class I soluble HLA (sHLA-I) in patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), polymyositis or dermatomyositis (PM/DM) or scleroderma and to assess the possible influence of ethnic factors on concentration in each disease group.
Solid-phase enzyme linked immunoassay was used to measure sHLA-I in the serum of 385 patients with varied ethnic backgrounds (American-Caucasians, African-Americans, Georgian-Caucasians) with rheumatic diseases. Studies on patients were compared to similar measurements of 189 healthy individuals.
Mean sHLA-I levels were significantly higher in patients with SLE than those observed in healthy individuals or other rheumatic diseases. Highest concentrations were present in Georgian-Caucasian patients with SLE. American-Caucasian patients with RA or scleroderma had higher sHLA-I levels than normal Caucasian individuals. The majority of patients with PM/DM in all ethnic subgroups were low secretors of sHLA-I.
Mechanisms underlying the secretion of sHLA-I appear to differ among the rheumatic diseases studied and various ethnic groups. These genetic differences in sHLA-I secretion could be associated with ethnic and pathophysiologic differences among these rheumatic diseases.
研究系统性红斑狼疮（SLE）、类风湿关节炎（RA）、多发性肌炎或皮肌炎（PM/DM）或硬皮病患者血清中Ⅰ类可溶性人类白细胞抗原（sHLA - I）水平，并评估种族因素对各疾病组浓度的可能影响。
采用固相酶联免疫分析法测定385例具有不同种族背景（美国白种人、非裔美国人、格鲁吉亚白种人）的风湿性疾病患者血清中的sHLA - I。将患者的研究结果与189名健康个体的类似测量结果进行比较。
SLE患者的平均sHLA - I水平显著高于健康个体或其他风湿性疾病患者。格鲁吉亚白种人SLE患者的浓度最高。患有RA或硬皮病的美国白种人患者的sHLA - I水平高于正常白种人个体。所有种族亚组中的大多数PM/DM患者都是sHLA - I的低分泌者。
在所研究的风湿性疾病和不同种族群体中，sHLA - I分泌的潜在机制似乎有所不同。sHLA - I分泌的这些基因差异可能与这些风湿性疾病之间的种族和病理生理差异有关。
