米非司酮与甲氨蝶呤联合治疗异位妊娠：一项II期非随机研究。
Treating ectopic pregnancy with the combination of mifepristone and methotrexate: a phase II nonrandomized study.
作者信息
Perdu M, Camus E, Rozenberg P, Goffinet F, Chastang C, Philippe H J, Nisand I
机构信息
Department of Gynecology and Obstetrics, Poissy Hospital, University of Paris V, France.
出版信息
Am J Obstet Gynecol. 1998 Sep;179(3 Pt 1):640-3. doi: 10.1016/s0002-9378(98)70057-2.
OBJECTIVE
Our goal was to compare the use of a combination of methotrexate and mifepristone with methotrexate alone in the medical management of ectopic pregnancy.
STUDY DESIGN
This was a preliminary nonrandomized phase II study. All patients with progressing ectopic pregnancy meeting criteria for medical management were included. Treatment consisted of 50 mg/m2 of methotrexate injected intramuscularly and 600 mg of mifepristone, administered orally, compared with a previous group who received only 50 mg/m2 of methotrexate injected intramuscularly.
RESULTS
Of the 30 patients treated with the combination, there was only 1 failure, whereas medical treatment had failed for 11 of 42 patients treated with methotrexate alone.
CONCLUSIONS
The combination of mifepristone and methotrexate decreased the risk of failure in medical treatment of ectopic pregnancy.
目的
我们的目标是比较甲氨蝶呤与米非司酮联合使用和单独使用甲氨蝶呤在异位妊娠药物治疗中的效果。
研究设计
这是一项初步的非随机II期研究。纳入了所有符合药物治疗标准且异位妊娠病情进展的患者。治疗方法为肌肉注射50mg/m²甲氨蝶呤和口服600mg米非司酮，与之前仅接受肌肉注射50mg/m²甲氨蝶呤的一组患者进行比较。
结果
在接受联合治疗的30例患者中，仅有1例治疗失败，而在单独接受甲氨蝶呤治疗的42例患者中，有11例治疗失败。
结论
米非司酮与甲氨蝶呤联合使用降低了异位妊娠药物治疗失败的风险。
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