Donovan E F, Ehrenkranz R A, Shankaran S, Stevenson D K, Wright L L, Younes N, Fanaroff A A, Korones S B, Stoll B J, Tyson J E, Bauer C R, Lemons J A, Oh W, Papile L A
University of Cincinnati, Ohio, USA.
Am J Obstet Gynecol. 1998 Sep;179(3 Pt 1):742-9. doi: 10.1016/s0002-9378(98)70075-4.
The study's aim was to compare outcomes of very low birth weight twins with those of matched singletons.
With data from the Neonatal Research Network registry (May 1991 to December 1994), univariable and multivariable comparisons of very low birth weight twin pairs and singletons were performed in 2 subgroups: (1) all paired twins and singletons with birth weights between 401 and 1500 g and (2) all paired twins and singletons born at <28 weeks' gestation.
Twins constituted 19% of infants admitted with very low birth weight. Mothers of twins were more likely to receive prenatal care, have labor, have cesarean delivery, and receive antenatal glucocorticoids. Twins were more likely to have respiratory disease and to receive surfactant. Second-born twins had more early respiratory disease but similar longer-term outcomes. The risks of death, chronic lung disease, and grade III or IV intracranial hemorrhage were similar in twins and singletons.
Although very low birth weight twins compose a sizable proportion of admissions, in National Institute of Child Health and Human Development Neonatal Research Network intensive care units, twins and singletons have similar outcomes.
本研究旨在比较极低出生体重双胞胎与匹配的单胎婴儿的结局。
利用新生儿研究网络登记处（1991年5月至1994年12月）的数据，对极低出生体重双胞胎和单胎婴儿进行单变量和多变量比较，分为2个亚组：（1）所有出生体重在401至1500克之间的配对双胞胎和单胎婴儿；（2）所有孕龄小于28周出生的配对双胞胎和单胎婴儿。
双胞胎占极低出生体重入院婴儿的19%。双胞胎的母亲更有可能接受产前护理、分娩、剖宫产并接受产前糖皮质激素治疗。双胞胎更有可能患呼吸系统疾病并接受表面活性剂治疗。第二个出生的双胞胎早期呼吸系统疾病更多，但长期结局相似。双胞胎和单胎婴儿在死亡、慢性肺病和III或IV级颅内出血方面的风险相似。
尽管极低出生体重双胞胎占入院人数的相当比例，但在美国国立儿童健康与人类发展研究所新生儿研究网络重症监护病房中，双胞胎和单胎婴儿的结局相似。
