Moore C P, Halenda R M, Grevan V L, Collins B K
Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia 65211, USA.
Equine Vet J. 1998 Sep;30(5):366-72. doi: 10.1111/j.2042-3306.1998.tb04503.x.
Traumatic keratouveitis in horses is characterised by a unilateral, aseptic, vascularising keratitis accompanied by moderate to severe anterior uveitis. In a series of 9 cases of post traumatic keratouveitis, topical and systemic nonsteroidal drugs and atropine were used to control the anterior uveitis while allowing spontaneous corneal healing. Among the 9 cases reported, 6 affected eyes previously treated with local corticosteroids took significantly longer to resolve when compared to 3 eyes in which corticosteroids had not been administered. It was concluded that, in cases of equine post traumatic keratouveitis, locally administered corticosteroids inhibit healing of damaged corneal stroma and, by prolonging the keratitis, perpetuate the concurrent anterior uveitis.
马的外伤性角膜葡萄膜炎的特征为单侧、无菌性、血管化角膜炎,并伴有中度至重度前葡萄膜炎。在一系列9例外伤性角膜葡萄膜炎病例中,使用局部和全身非甾体类药物及阿托品来控制前葡萄膜炎,同时让角膜自发愈合。在报告的9例病例中,与未使用皮质类固醇的3只眼相比,先前接受局部皮质类固醇治疗的6只患眼的炎症消退时间明显更长。得出的结论是,在马外伤性角膜葡萄膜炎病例中,局部使用皮质类固醇会抑制受损角膜基质的愈合,并通过延长角膜炎的时间,使并发的前葡萄膜炎持续存在。