Fami M J, Ho N T, Mason C M
School of Pharmacy, Northeast Louisiana University, Monroe 71209, USA.
Pharmacotherapy. 1998 Sep-Oct;18(5):1133-5.
Numerous case reports in the literature describe adverse drug events associated with immediate-release nifedipine (IRN). In addition, several publications alerted health care professionals regarding the agent. However, it is still administered, and adverse reactions are still reported. Our patient suffered IRN-induced hypotension, myocardial ischemia, and mental status changes. We recommend that the use of IRN in treatment of hypertension should be either totally prohibited or severely restricted. The product should not be readily available for indiscriminate administration. Also, continuing education and training are required to alert all health care professionals to the serious dangers associated with this drug.
文献中的大量病例报告描述了与速释硝苯地平（IRN）相关的药物不良事件。此外，一些出版物已就该药物向医护人员发出警示。然而，它仍在使用，不良反应仍有报告。我们的患者出现了IRN诱发的低血压、心肌缺血和精神状态改变。我们建议应完全禁止或严格限制使用IRN治疗高血压。该产品不应随意提供以供滥用。此外，需要持续开展教育和培训，以使所有医护人员认识到与这种药物相关的严重危险。
