Department of Chemistry, College of Sciences, Shanghai University, Shanghai, 200444, People's Republic of China.
Department of Urology, School of Medicine, Shanghai First People's Hospital, Shanghai Jiaotong University, Shanghai, 200080, People's Republic of China.
Mikrochim Acta. 2024 May 15;191(6):332. doi: 10.1007/s00604-024-06407-z.
Nifedipine (NIF), as one of the dihydropyridine calcium channel blockers, is widely used in the treatment of hypertension. However, misuse or ingestion of NIF can result in serious health issues such as myocardial infarction, arrhythmia, stroke, and even death. It is essential to design a reliable and sensitive detection method to monitor NIF. In this work, an innovative molecularly imprinted polymer dual-emission fluorescent sensor (CDs@PDA-MIPs) strategy was successfully designed for sensitive detection of NIF. The fluorescent intensity of the probe decreased with increasing NIF concentration, showing a satisfactory linear relationship within the range 1.0 × 10 M ~ 5.0 × 10 M. The LOD of NIF was 9.38 × 10 M (S/N = 3) in fluorescence detection. The application of the CDs@PDA-MIPs in actual samples such as urine and Qiangli Dingxuan tablets has been verified, with recovery ranging from 97.8 to 102.8% for NIF. Therefore, the fluorescent probe demonstrates great potential as a sensing system for detecting NIF.
硝苯地平（NIF）作为二氢吡啶类钙通道阻滞剂之一，被广泛用于治疗高血压。然而，NIF 的误用或摄入会导致严重的健康问题，如心肌梗死、心律失常、中风，甚至死亡。因此，设计一种可靠、灵敏的检测方法来监测 NIF 至关重要。在这项工作中，成功设计了一种创新的分子印迹聚合物双发射荧光传感器（CDs@PDA-MIPs）策略，用于灵敏检测 NIF。探针的荧光强度随 NIF 浓度的增加而降低，在 1.0×10^-6 M5.0×10^-6 M 范围内呈现出令人满意的线性关系。在荧光检测中，NIF 的检出限为 9.38×10^-6 M（S/N=3）。已经验证了 CDs@PDA-MIPs 在实际样品（如尿液和强力定眩片）中的应用，NIF 的回收率在 97.8%102.8%之间。因此，该荧光探针作为检测 NIF 的传感系统具有很大的潜力。
