Chen B, Wang X, Yu J, Zhang G, Chen F, Den J, Fu S, Li P, Cao W, Yu H
Laboratory of Medical Genetics, Harbin Medical University, Harbin, Heilongjiang, 150086 P. R. China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 1998 Oct 10;15(5):300-2.
This study inquired into the relationship between methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and coronary heart disease.
By polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP), MTHFR 677C-->T mutation was detected in 79 healthy controls and 69 patients with coronary heart disease.
The frequency of MTHFR variant V677 of patients was significantly higher than that of healthy controls (P<0.01).
This study demonstrated that MTHFR gene V677 mutation was probably one of the genetic risk factors of coronary heart disease and this provided a new basis for exploring the relevant pathogenesis.
