[Relationship between methylenetetrahydrofolate reductase gene polymorphism and coronary heart disease].
作者信息
Chen B, Wang X, Yu J, Zhang G, Chen F, Den J, Fu S, Li P, Cao W, Yu H
机构信息
Laboratory of Medical Genetics, Harbin Medical University, Harbin, Heilongjiang, 150086 P. R. China.
出版信息
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 1998 Oct 10;15(5):300-2.
OBJECTIVE
This study inquired into the relationship between methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and coronary heart disease.
METHODS
By polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP), MTHFR 677C-->T mutation was detected in 79 healthy controls and 69 patients with coronary heart disease.
RESULTS
The frequency of MTHFR variant V677 of patients was significantly higher than that of healthy controls (P<0.01).
CONCLUSION
This study demonstrated that MTHFR gene V677 mutation was probably one of the genetic risk factors of coronary heart disease and this provided a new basis for exploring the relevant pathogenesis.
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