Chaussepied P, Smyczynski C, Van Dijk J
Centre de Recherches de Biochimie macromoléculaire, UPR1086 du CNRS, IFR24, Montpellier.
C R Seances Soc Biol Fil. 1998;192(2):319-34.
Cytoskeleton based molecular motors support most of the cellular movements and by consequence they are associated with a variety of human disorders. The wide functional diversity of these molecular motors is now explained by the presence of three different families: the myosin, kinesin and dynein families. Although they are functionally distinct, these motors present unexpected structural homologies at the ATP and actin or microtubule binding sites. However, these homologies do not seem sufficient to design a common molecular mechanism which allows these proteins to move along the cytoskeleton.
基于细胞骨架的分子马达支持大多数细胞运动，因此它们与多种人类疾病相关。这些分子马达广泛的功能多样性现在可以通过存在三个不同的家族来解释：肌球蛋白、驱动蛋白和动力蛋白家族。尽管它们在功能上不同，但这些马达在ATP与肌动蛋白或微管结合位点呈现出意想不到的结构同源性。然而，这些同源性似乎不足以设计出一种共同的分子机制，使这些蛋白质能够沿着细胞骨架移动。
