Bridi A A, Rehbein S, Carvalho L A, Barth D, Barrick R A, Eagleson J S
Merial Limited, Uruguaiana RS., Brazil.
Vet Parasitol. 1998 Aug 14;78(3):215-21. doi: 10.1016/s0304-4017(98)00123-x.
Three trials including 42 sheep were conducted in Brazil or Germany to evaluate the therapeutic (two trials) and prophylactic (one trial) efficacy of an ivermectin controlled release capsule (CRC) against Psoroptes ovis infestation. In one therapeutic trial naturally infested sheep were used while in the other trials infestations were experimentally induced. In each trial half of the animals were treated on Day 0 with one ivermectin controlled release capsule that delivers ivermectin at a rate of 1.6 mg/day for approximately 100 days, that is 20 mcg/kg/day to a 80 kg animal, while the other half remained untreated. In both therapeutic trials mites were counted in skin scrapings and their presence was recorded at predilection sites one day before treatment and at weekly intervals from Day 7 to Day 56. In the trial conducted to evaluate the prophylactic efficacy the sheep were experimentally infested with P. ovis 21 and 28 days post-treatment and mites were counted and recorded at predilection sites on Days 42, 49 and 56. The ivermectin controlled release capsule was completely effective in eliminating the P. ovis mites within 28 days of administration and it prevented the establishment of an infestation of P. ovis induced 21 and 28 days after administration.
在巴西或德国进行了三项试验，涉及42只绵羊，以评估伊维菌素控释胶囊（CRC）对绵羊痒螨感染的治疗（两项试验）和预防（一项试验）效果。在一项治疗试验中使用自然感染的绵羊，而在其他试验中感染是通过实验诱导的。在每项试验中，一半的动物在第0天接受一粒伊维菌素控释胶囊治疗，该胶囊以每天1.6毫克的速率释放伊维菌素，持续约100天，即对于一只80公斤的动物为每天20微克/公斤，而另一半不进行治疗。在两项治疗试验中，在治疗前一天以及从第7天到第56天每周对皮肤刮屑中的螨虫进行计数，并在好发部位记录其存在情况。在评估预防效果的试验中，绵羊在治疗后21天和28天通过实验感染绵羊痒螨，并在第42天、第49天和第56天在好发部位对螨虫进行计数和记录。伊维菌素控释胶囊在给药后28天内完全有效地消除了绵羊痒螨，并且预防了给药后21天和28天诱导的绵羊痒螨感染的发生。
