Sonnenfeld G, Foster M, Morton D, Bailliard F, Fowler N A, Hakenewerth A M, Bates R, Miller E S
Department of General Surgery Research, Carolinas Medical Center, Charlotte, North Carolina 28232-2861, USA.
J Appl Physiol (1985). 1998 Oct;85(4):1429-33. doi: 10.1152/jappl.1998.85.4.1429.
The NIH.R1 Space Shuttle experiment was designed to study the effects of spaceflight on rodent development. Pregnant rats were flown on the Space Shuttle for 11 days, and pregnant control rats were maintained in animal enclosure modules in a ground-based chamber under conditions approximating those in flight. Additional controls were in standard housing. The effects of the flight on immunological parameters of dams, fetuses, and pups were determined. Blastogenesis of spleen cells in response to mitogen was inhibited in flown dams but was not inhibited in cells from their pups. Interferon-gamma production by spleen cells showed a trend toward inhibition in flown dams but not in their pups. The response of bone marrow cells to colony-stimulating factor showed a trend toward inhibition after spaceflight in dams, but the response of fetus and pup liver cells was not inhibited. Total serum IgG was not affected by spaceflight. None of the examined immune parameters that were altered in rat dams after spaceflight was found to be altered in their offspring.
美国国立卫生研究院（NIH）的R1航天飞机实验旨在研究太空飞行对啮齿动物发育的影响。怀孕大鼠搭乘航天飞机飞行11天，怀孕的对照大鼠则被安置在地面舱室的动物饲养模块中，所处条件与飞行中的近似。另外设置了标准饲养环境的对照组。研究了飞行对母鼠、胎儿和幼崽免疫参数的影响。飞行后的母鼠脾脏细胞对有丝分裂原的增殖反应受到抑制，但其幼崽细胞未受抑制。脾脏细胞产生的γ干扰素在飞行后的母鼠中呈抑制趋势，在其幼崽中则不然。骨髓细胞对集落刺激因子的反应在飞行后的母鼠中呈抑制趋势，但胎儿和幼崽的肝细胞反应未受抑制。血清总IgG不受太空飞行影响。在太空飞行后母鼠中发生改变的免疫参数，在其后代中均未发现有改变。
