硫胺素和蛋氨酸给药对预防镉诱导的雄性大鼠生化改变及金属浓度的影响。

Effects of thiamin and methionine administration in preventing cadmium-induced biochemical alterations and metal concentration in male rats.

作者信息

Gubrelay U, Srivastava P, Mathur R, Tripathi N, Flora S J

机构信息

School of Studies in Zoology, Jiwaji University, Gwalior, India.

出版信息

J Trace Elem Med Biol. 1998 Jul;12(2):86-90. doi: 10.1016/S0946-672X(98)80030-8.

DOI:10.1016/S0946-672X(98)80030-8

PMID:9760416

Abstract

Thiamin or methionine supplementation was equally and moderately effective in preventing the accumulation of cadmium in soft organs and alterations in a few selected biochemical indices during concomitant administration. Adequate intake of sulfur amino acid following methionine supplementation might increase the bioavailability of glutathione, facilitating the prevention of the binding of cadmium to different compartments and consequently reversing cadmium-induced biochemical disorders. In the case of thiamine the possibility of formation of a readily excretable complex between cadmium and thiamine or an increase in the body's resistance to cadmium might be the beneficial factor.

摘要

在同时给药期间，补充硫胺素或蛋氨酸在预防镉在软组织器官中的蓄积以及一些选定生化指标的改变方面具有同等且适度的效果。补充蛋氨酸后充足摄入含硫氨基酸可能会提高谷胱甘肽的生物利用度，有助于防止镉与不同部位结合，从而逆转镉诱导的生化紊乱。就硫胺素而言，镉与硫胺素之间形成易于排泄的复合物的可能性或机体对镉抵抗力的增加可能是有益因素。