螯合剂对镉诱导的肝毒性的抑制作用。

Chelating-agent suppression of cadmium-induced hepatotoxicity.

作者信息

Basinger M A, Jones M M, Craft W D, Walker E M, Sanders M M

机构信息

Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235.

出版信息

J Toxicol Environ Health. 1987;22(3):261-71. doi: 10.1080/15287398709531070.

DOI:10.1080/15287398709531070

PMID:2890768

Abstract

The administration of sodium N-methyl-N-dithiocarboxy-D-glucamine (NaG) at 500 mg/kg, i.p., or sodium calcium diethylenetriaminepentaacetic acid (DTPA) at 632.5 mg/kg, i.p., reduces the serum enzyme levels characteristic of hepatic damage following the intravenous administration of cadmium chloride (3.5 mg CdCl2.2.5H2O/kg). Some effect on serum enzyme levels was found even when the interval between administration of cadmium chloride and that of the antagonist was as great as 4 h. The enzymes examined included aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), alanine aminotransferase (SGPT), and alkaline phosphatase (AP). A histopathological examination of the livers of such animals also reveals the presence of a significant protective action.

摘要

腹腔注射500毫克/千克的N-甲基-N-二硫代羧基-D-葡糖胺钠（NaG）或腹腔注射632.5毫克/千克的二乙烯三胺五乙酸钙钠（DTPA），可降低静脉注射氯化镉（3.5毫克CdCl₂·2.5H₂O/千克）后肝脏损伤所特有的血清酶水平。即使氯化镉与拮抗剂给药之间的间隔长达4小时，仍发现对血清酶水平有一定影响。检测的酶包括天冬氨酸转氨酶（AST）、γ-谷氨酰转肽酶（GGT）、丙氨酸转氨酶（SGPT）和碱性磷酸酶（AP）。对这些动物肝脏的组织病理学检查也显示出明显的保护作用。