Rodrigues M, Shelton K, Glaser E, Higginbotham E
Department of Ophthalmology, University of Maryland School of Medicine, Baltimore, USA.
Ophthalmic Surg Lasers. 1998 Sep;29(9):758-61.
To study tissue effects and thresholds of efficacy in producing a full-thickness scleral fistula in human eyes obtained from cadavers. The effect of laser sclerostomies created with indocyanine green (ICG) was also evaluated.
Ab externo laser sclerostomies were produced in 12 fresh human eyes obtained from cadavers using a 200-micron diameter fiber optic connected to a diode laser system. Power settings were 500, 750, 1000, 1250, 1500, and 2000 mW with a constant duration of 100 and 200 ms. The same diode laser settings were repeated in the tissues injected with ICG.
The laser sclerostomies were associated with heat coagulation damage adjacent to the burn margins, with disruption of stromal collagen. Tissue damage was greater at higher power and longer duration. Scleral injection of ICG prior to laser sclerostomy did not enhance laser penetration.
The diode laser can create a sclerostomy in human sclera with an optimum level of 1500 mW and 100 ms. ICG did not significantly enhance the ease of penetration or reduce the association thermal damage to the sclera.
研究在取自尸体的人眼中制造全层巩膜瘘管的组织效应和有效阈值。还评估了用吲哚菁绿（ICG）进行激光巩膜造口术的效果。
使用连接到二极管激光系统的200微米直径光纤，在取自尸体的12只新鲜人眼中进行外路激光巩膜造口术。功率设置为500、750、1000、1250、1500和2000毫瓦，持续时间恒定为100和200毫秒。在注射ICG的组织中重复相同的二极管激光设置。
激光巩膜造口术与烧伤边缘附近的热凝固损伤相关，伴有基质胶原的破坏。在较高功率和较长持续时间下，组织损伤更大。在激光巩膜造口术前巩膜注射ICG并未增强激光穿透。
二极管激光可以在人巩膜中制造巩膜造口术，最佳水平为1500毫瓦和100毫秒。ICG并未显著提高穿透的容易程度或减少对巩膜的相关热损伤。
