Swierblewska E, Chrostowska M, Dudziak M, Jagoda J, Winnicki M, Narkiewicz K, Pawłowski R, Krupa-Wojciechowska B
Klinika Nadciśnienia Tetniczego i Diabetologii AM w Gdańsku.
Pol Arch Med Wewn. 1998 Mar;99(3):203-10.
It has been reported that the allel D of an insertion/deletion (I/D) polymorphism of the angiotensin I converting enzyme (ACE) gene is associated with the conditions of increased cardiovascular risk, including the left ventricular hypertrophy and the dysfunction. We examined the relation between the genotype of ACE gene and the left ventricular function in normotensives and in borderline, mild and moderate hypertensives. We investigated 128 subjects, 47 first-diagnosed untreated hypertensives and 81 normotensives. The M-mode and Doppler echocardiography were used to quantify LV mass and function. The insertion/deletion ACE polymorphism was identified using polymerase chain reaction. Left ventricular indexes of the morphology and function were analyzed. We compared ambulatory blood pressure profiles between all genotypes in both groups. There were no significant differences in indexes of the left ventricular hypertrophy in studied normotensives and borderline to mild hypertensives. Our results indicate that allel I might be associated with selected parameters of diastolic function, while allel D with selected parameters of systolic function, of the left ventricle. Results of this study suggest also probable relation between allel D and variability of the diastolic arterial pressure in both investigated groups.
据报道，血管紧张素I转换酶（ACE）基因插入/缺失（I/D）多态性的D等位基因与心血管风险增加的情况有关，包括左心室肥厚和功能障碍。我们研究了ACE基因的基因型与正常血压者以及临界、轻度和中度高血压患者左心室功能之间的关系。我们调查了128名受试者，其中47名是首次诊断未经治疗的高血压患者，81名是正常血压者。采用M型和多普勒超声心动图来量化左心室质量和功能。使用聚合酶链反应鉴定ACE基因的插入/缺失多态性。分析左心室形态和功能指标。我们比较了两组中所有基因型的动态血压情况。在研究的正常血压者以及临界至轻度高血压患者中，左心室肥厚指标没有显著差异。我们的结果表明，I等位基因可能与左心室舒张功能的特定参数相关，而D等位基因与左心室收缩功能的特定参数相关。本研究结果还表明，在两个研究组中，D等位基因与舒张压变异性之间可能存在关联。
