von Greyerz S, Zanni M, Schnyder B, Pichler W J
Institute of Immunology and Allergology, Inselspital, Bern, Switzerland.
Clin Exp Allergy. 1998 Sep;28 Suppl 4:7-11.
Drugs are non-peptide antigens that can be recognized by specific T cells. It has been thought for many years that small molecular compounds can only be stimulating for T cells after covalent binding to MHC-embedded peptides. As most drug-specific T cell clones can react to glutaraldehyde fixed antigen presenting cells (APC), recognition of drugs by specific T cells does not require prior uptake and processing of haptenated proteins by APC. In fact, activated T cell clones can recognize drugs associated with the MHC-peptide complex in a non-covalent way. Such a binding is reminiscent of superantigen stimulations of T cells.
药物是非肽类抗原，可被特异性T细胞识别。多年来人们一直认为，小分子化合物只有在与嵌入MHC的肽共价结合后才能刺激T细胞。由于大多数药物特异性T细胞克隆能与戊二醛固定的抗原呈递细胞（APC）发生反应，特异性T细胞对药物的识别并不需要APC预先摄取和处理半抗原化蛋白。事实上，活化的T细胞克隆能够以非共价方式识别与MHC-肽复合物相关的药物。这种结合使人联想到T细胞的超抗原刺激。
