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过期妊娠引产:一项观察性研究。

Induction of labour for post term pregnancy: an observational study.

作者信息

Parry E, Parry D, Pattison N

机构信息

Department of Obstetrics and Gynaecology, National Women's Hospital, Auckland, New Zealand.

出版信息

Aust N Z J Obstet Gynaecol. 1998 Aug;38(3):275-80. doi: 10.1111/j.1479-828x.1998.tb03065.x.

Abstract

The aim of the study was to compare the 2 management protocols for postterm pregnancy; elective induction of labour at 42 weeks' gestation and continuing the pregnancy with fetal monitoring while awaiting spontaneous labour. A retrospective observational study compared a cohort of 360 pregnancies where labour was induced with 486 controls. All pregnancies were postterm (>294 days) by an early ultrasound scan. Induction of labour was achieved with either prostaglandin vaginal pessaries or gel or forewater rupture and Syntocinon infusion. The control group consisted of women with postterm pregnancies who were not induced routinely and who usually had twice weekly fetal assessment with cardiotocography and/or ultrasound. Women who had their labour induced differed from those who awaited spontaneous labour. Nulliparas (OR 1.54; 95% CI 1.24-1.83) and married women (OR 1.76; 95% CI 1.45-2.06) were more likely to have their labour induced. There was no association between the type of caregiver and induction of labour. Induction of labour was associated with a reduction in the incidence of normal vaginal delivery (OR 0.63, 95% CI 0.43-0.92) and an increased incidence of operative vaginal delivery (OR 1.46; 95% CI 1.34-2.01). There was no difference in the overall rate of Caesarean section. There was no difference in fetal or neonatal outcomes. Parity had a major influence on delivery outcomes from a policy of induction of labour. Nulliparas in the induced group had worse outcomes with only 43% achieving a normal vaginal delivery (OR 0.78, 95% CI 0.65-0.95). In contrast for multiparas, the induced group had better outcomes with less Caesarean sections (OR 0.88, 95% CI 0.81-0.96). This retrospective observational study of current clinical practice shows that induction of labour for postterm pregnancy appears to be favoured by nulliparous married women. It suggests that induction of labour may improve delivery outcomes for multigravas but has an adverse effect for nulliparas.

摘要

本研究的目的是比较过期妊娠的两种管理方案

妊娠42周时择期引产以及在等待自然分娩期间通过胎儿监测继续妊娠。一项回顾性观察性研究比较了360例引产妊娠的队列与486例对照。所有妊娠均通过早期超声扫描确定为过期妊娠(>294天)。引产通过前列腺素阴道栓剂或凝胶或人工破膜及缩宫素静脉滴注来实现。对照组由未常规引产的过期妊娠妇女组成,这些妇女通常每周进行两次胎儿评估,包括胎心监护和/或超声检查。引产的妇女与等待自然分娩的妇女有所不同。初产妇(比值比1.54;95%可信区间1.24 - 1.83)和已婚妇女(比值比1.76;95%可信区间1.45 - 2.06)更有可能接受引产。护理人员类型与引产之间没有关联。引产与正常阴道分娩发生率降低(比值比0.63,95%可信区间0.43 - 0.92)以及手术助产分娩发生率增加(比值比1.46;95%可信区间1.34 - 2.01)相关。剖宫产的总体发生率没有差异。胎儿或新生儿结局没有差异。产次对引产政策的分娩结局有重大影响。引产组的初产妇结局较差,只有43%实现正常阴道分娩(比值比0.78,95%可信区间0.65 - 0.95)。相比之下,经产妇中,引产组结局较好,剖宫产较少(比值比0.88,95%可信区间0.81 - 0.96)。这项对当前临床实践的回顾性观察性研究表明,初产已婚妇女似乎更倾向于过期妊娠引产。这表明引产可能改善多产妇的分娩结局,但对初产妇有不利影响。

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