Flo G, Vermaut S, Van Boven M, Daenens P, Buyse J, Decuypere E, Kühn E, Cokelaere M
Interdisciplinary Research Centre, Katholieke Universiteit Leuven Campus Kortrijk, Belgium.
Horm Metab Res. 1998 Aug;30(8):504-8. doi: 10.1055/s-2007-978921.
In this study, we investigated the analogies between the physiological effects of simmondsin, a satiety-inducing glycoside extracted from jojoba seeds, and the gastro-intestinal satiation peptide, cholecystokinin. The effects of intraperitoneal injection of the biological active CCK-octapeptide on the pancreas, interscapular brown adipose tissue, growth performance and energy metabolism in normal-fed, severely food intake-restricted (50 % of normal food intake) or moderately food intake-restricted (65 % of normal food intake) growing rats were compared to the effects of 0.25 % simmondsin mixed in the food, inducing moderate food intake reduction (65 % of normal) in rats. Cholecystokinin induced pancreatic hypertrophy. In normal fed rats, cholecystokinin had no effect on brown adipose tissue or growth, while, in severely food intake-restricted rats, it caused brown adipose tissue hypertrophy and reduced growth. In moderately food intake-restricted rats, both cholecystokinin and simmondsin induced pancreatic hypertrophy, increased brown adipose weight and metabolism and caused a slight decrease in growth. We conclude that cholecystokinin may decrease growth performance in fast growing severely food intake-restricted rats by stimulating brown adipose tissue metabolism, probably because of protein shortage induced by pancreatic hyperstimulation. Simmondsin has similar effects. These results support the hypothesis that endogenous cholecystokinin is involved in the effects of simmondsin in rats.
在本研究中，我们调查了从霍霍巴种子中提取的一种诱导饱腹感的糖苷——西蒙德辛的生理效应与胃肠饱腹感肽——胆囊收缩素之间的相似性。将腹腔注射生物活性胆囊收缩素八肽对正常喂食、严重食物摄入量受限（正常食物摄入量的50%）或中度食物摄入量受限（正常食物摄入量的65%）的生长大鼠的胰腺、肩胛间棕色脂肪组织、生长性能和能量代谢的影响，与食物中混合0.25%西蒙德辛对大鼠的影响进行了比较，后者会使大鼠食物摄入量适度减少（正常摄入量的65%）。胆囊收缩素可诱导胰腺肥大。在正常喂食的大鼠中，胆囊收缩素对棕色脂肪组织或生长没有影响，而在严重食物摄入量受限的大鼠中，它会导致棕色脂肪组织肥大并减缓生长。在中度食物摄入量受限的大鼠中，胆囊收缩素和西蒙德辛都会诱导胰腺肥大，增加棕色脂肪重量和代谢，并导致生长略有下降。我们得出结论，胆囊收缩素可能通过刺激棕色脂肪组织代谢来降低快速生长且严重食物摄入量受限的大鼠的生长性能，这可能是由于胰腺过度刺激导致蛋白质短缺所致。西蒙德辛也有类似的作用。这些结果支持了内源性胆囊收缩素参与西蒙德辛对大鼠作用的假说。
