Cokelaere M, Daenens P, Decuypere E, Flo G, Kühn E, Van Boven M, Vermaut S
Interdisciplinary Research Center, Katholieke Universiteit Leuven Campus Kortrijk, Belgium.
Food Chem Toxicol. 1998 Jan;36(1):13-9. doi: 10.1016/s0278-6915(97)00118-x.
The effects on food intake, growth and reproductive performance parameters of defatted jojoba meal and pure simmondsin, an extract from jojoba meal, were compared in female Wistar rats. Rats fed 0.15% simmondsin or 3% defatted jojoba meal (equivalent to 0.15% simmondsin) for 8 weeks before conception showed a similar reduction in food intake (about 20%) and a similar growth retardation compared with controls. Both treatments induced a reduction in the number of corpora lutea on gestation day 16: this effect could be ascribed to the lower food intake before conception because it was also observed in rats pair-fed to the treated ones. Rats given feed containing 0.15% simmondsin or 3% defatted jojoba meal during days 1-16 of gestation showed a similar reduction in food intake relative to controls. Foetal and placental weights were reduced, relative to controls, to a similar extent in both groups, and the reductions were slightly greater than in the corresponding pair-fed groups. We conclude that the effects on food intake, growth and reproductive performance that were seen after feeding rats defatted jojoba meal were due to the simmondsin content of the meal. The simmondsin induced reduction in food intake and probably also a relative protein shortage.
在雌性Wistar大鼠中，比较了脱脂荷荷巴粕及荷荷巴粕提取物纯西蒙德辛对食物摄入量、生长及生殖性能参数的影响。在受孕前8周，喂食0.15%西蒙德辛或3%脱脂荷荷巴粕（相当于0.15%西蒙德辛）的大鼠，与对照组相比，食物摄入量出现类似程度的减少（约20%），生长发育也出现类似程度的迟缓。两种处理均导致妊娠第16天黄体数量减少：这种效应可能归因于受孕前较低的食物摄入量，因为在与处理组配对喂食的大鼠中也观察到了这一现象。在妊娠第1至16天，喂食含0.15%西蒙德辛或3%脱脂荷荷巴粕饲料的大鼠，相对于对照组，食物摄入量出现类似程度的减少。与对照组相比，两组的胎儿和胎盘重量均出现类似程度的降低，且降低幅度略大于相应的配对喂食组。我们得出结论，喂食大鼠脱脂荷荷巴粕后观察到的对食物摄入量、生长及生殖性能的影响，是由于该粕中西蒙德辛的含量所致。西蒙德辛导致食物摄入量减少，可能还导致了相对的蛋白质缺乏。
