Preliminary X-ray crystallographic studies of a newly defined human theta-class glutathione transferase.

作者信息

McKinstry W J, Oakley A J, Rossjohn J, Verger D, Tan K L, Board P G, Parker M W

机构信息

The Ian Potter Foundation Protein Crystallography Laboratory, St Vincent's Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia.

出版信息

Acta Crystallogr D Biol Crystallogr. 1998 Jan 1;54(Pt 1):148-50. doi: 10.1107/s0907444997008366.

DOI:10.1107/s0907444997008366

PMID:9761841

Abstract

Human theta-class glutathione S-transferases (GST's) appear to play a critical role in the metabolism of a variety of environmental pollutants but in some cases the products of the reaction are carcinogenic. Crystals of a human theta-class GST, namely hGSTT2-2, have been grown from polyethylene glycol by the hanging-drop vapour-diffusion method. The crystals belong to the trigonal space group P3121 with cell dimensions of a = b = 94.0 and c = 120.5 A. They contain two monomers in the asymmetric unit and diffract to 3.0 A resolution.

摘要