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螺内酯和氨氯吡咪对一名肝硬化腹水患者钾排泄的相反作用。

Opposite effects of spironolactone and amiloride on potassium excretion in a patient with ascites due to liver cirrhosis.

作者信息

Radó J P, Juhos E

出版信息

Endokrinologie. 1976 Jul;67(3):377-9.

PMID:976213
Abstract

Potassium excretion was enhanced by spironolactone and it was inhibited by amiloride in a patient with ascites. One drug's effect was counteracted by the other when they were used in combination. Individual variation in the sites of action of antikaluretic drugs might be a possible explanation for the unpredictable changes in potassium excretion induced by these agents.

摘要

在一名腹水患者中,螺内酯可增强钾排泄,而氨氯吡咪则抑制钾排泄。当联合使用这两种药物时,一种药物的作用会被另一种药物抵消。抗利尿药物作用部位的个体差异可能是这些药物引起钾排泄不可预测变化的一个可能解释。

相似文献

1
Opposite effects of spironolactone and amiloride on potassium excretion in a patient with ascites due to liver cirrhosis.螺内酯和氨氯吡咪对一名肝硬化腹水患者钾排泄的相反作用。
Endokrinologie. 1976 Jul;67(3):377-9.
2
Reversal of the suppressed potassium excretion during treatment with combinations of antikaliuretic drugs (spironolactone, canrenone, triamterene, amiloride) in patients with liver cirrhosis.肝硬化患者在使用抗利尿钾药物(螺内酯、坎利酮、氨苯蝶啶、阿米洛利)联合治疗期间,被抑制的钾排泄得以逆转。
Int J Clin Pharmacol Biopharm. 1976 Oct;14(3):163-7.
3
Attenuation by spironolactone of the magnesiuric effect of acute frusemide administration in patients with liver cirrhosis and ascites.
Miner Electrolyte Metab. 1993;19(2):86-90.
4
[Treatment of cirrhotic edemas with triamterene, amiloride and spirolactone. New clinical and biological facts].用氨苯蝶啶、阿米洛利和螺内酯治疗肝硬化水肿。新的临床和生物学事实
Schweiz Med Wochenschr. 1971 Mar 20;101(11):398-401.
5
[Potassium-saving effects of amiloride, triamterene and spironolactone].
Verh Dtsch Ges Inn Med. 1976;82 Pt 2:1514-7.
6
Renal sodium and potassium excretion in sheep given amiloride.
Am J Vet Res. 1979 May;40(5):688-90.
7
Paradoxical reversal of the suppressed potassium secretion during treatment with combinations of antikaluretic agents (spironolactone, canrenone, triamterene, amiloride); a possible site of action in Henle's loop.使用抗利尿药(螺内酯、坎利酮、氨苯蝶啶、阿米洛利)联合治疗期间,受抑制的钾分泌出现反常逆转;亨利氏袢中一个可能的作用位点。
Horm Metab Res. 1976 May;8(3):250-1. doi: 10.1055/s-0028-1095614.
8
Amiloride (MK-870), a new antikaluretic diuretic. Comparison to other antikaluretic diuretics in patients with liver disease and ascites.氨氯吡咪(MK-870),一种新型抗利钾性利尿剂。与其他抗利钾性利尿剂在肝病和腹水患者中的比较。
Gastroenterology. 1970 Dec;59(6):833-41.
9
Antikaluretic action of amiloride.阿米洛利的抗利尿作用。
Acta Cardiol. 1973:Suppl 17:301-6.
10
[Effect of aldactone on potassium storage in patients with ascitic cirrhosis].
Ann Med Interne (Paris). 1970 Feb;121(2):183-90.