Kálman M, Tuba A
Department of Anatomy, Histology and Embryology, Semmelweis University of Medicine, Budapest, Hungary.
Int J Dev Neurosci. 1998 Apr;16(2):115-21. doi: 10.1016/s0736-5748(98)00007-0.
This paper compares the myelination in rat cortex and spinal cord transplanted on the embryonic day (E) 12, 14, 16, 18, 20 and right after birth (P0) into the anterior eye chamber of adult rats. Myelinated fibers were not observed in either cortical or spinal cord transplants of E12. When transplanted on E14, abundant myelinated fibers developed in the spinal cord and gathered at the periphery of the transplants as a "white matter". In the grafted cortex myelinated fibers were found when transplantation occurred on E16 or later. The myelinated fibers, however, remained scarce or formed only narrow bundles. The number and distribution of myelinated fibers did not depend on the donor's age between E16 and P0: even in the latter case transplanted cortex were found without myelination. The differences could be attributed to the different development of the cortical and spinal cord oligodendrocytes and to the different intrinsic organization of the grafted samples.
本文比较了在胚胎第12天（E12）、14天、16天、18天、20天以及出生后即刻（P0）移植到成年大鼠前房的大鼠皮层和脊髓中的髓鞘形成情况。在E12的皮层或脊髓移植中均未观察到有髓纤维。当在E14移植时，脊髓中发育出丰富的有髓纤维，并在移植体周边聚集形成“白质”。当在E16或更晚进行移植时，在移植的皮层中发现了有髓纤维。然而，有髓纤维仍然稀少或仅形成狭窄的束状。在E16至P0之间，有髓纤维的数量和分布并不取决于供体的年龄：即使在后一种情况下，也发现移植的皮层没有髓鞘形成。这些差异可能归因于皮层和脊髓少突胶质细胞的不同发育以及移植样本的不同内在组织结构。
