Reder A T, Genç K, Byskosh P V, Porrini A M
Department of Neurology, University of Chicago, Illinois 60637, USA.
Mult Scler. 1998 Jun;4(3):162-8. doi: 10.1177/135245859800400314.
Monocytes, macrophages, and microglia have a central role in the CNS inflammation of MS. Monocytes are important in the earliest events in MS. Peripheral blood monocytes secrete prostaglandins before MS attacks. During clinical activity monocyte activation markers increase and IL-1 and TNF-alpha levels are elevated. Other monocyte products such as IL-10 reduce inflammation. IL-10 mRNA in MNC is increased during stable disease. Manipulation of monokine secretion and expression of monocyte surface proteins are reasonable approaches for immune therapy of MS.
单核细胞、巨噬细胞和小胶质细胞在多发性硬化症的中枢神经系统炎症中起核心作用。单核细胞在多发性硬化症的早期事件中很重要。外周血单核细胞在多发性硬化症发作前分泌前列腺素。在临床活动期间，单核细胞激活标志物增加，白细胞介素-1和肿瘤坏死因子-α水平升高。其他单核细胞产物如白细胞介素-10可减轻炎症。在疾病稳定期，单核细胞中的白细胞介素-10信使核糖核酸增加。操纵单核因子分泌和单核细胞表面蛋白的表达是多发性硬化症免疫治疗的合理方法。
