Sharief M K
Department of Neurology, UMDS, Guy's Hospital, London, England.
Mult Scler. 1998 Jun;4(3):169-73. doi: 10.1177/135245859800400315.
The targets of the inflammatory response in multiple sclerosis (MS) are myelin and the myelin producing cells, oligodendrocytes. The infiltration of activated immune cells and recruitment of endogenous glia lead to the destruction of myelin and oligodendrocytes, a process that is compounded by the release of cytokines by infiltrating cells. Recent evidence suggests that key cytokines that are responsible for the destruction of myelin may also mediate the process of remyelination and repair. It appears that both inflammatory and repair processes are governed by the temporal and spatial relation of cytokines to their targets.
多发性硬化症（MS）中炎症反应的靶标是髓鞘和产生髓鞘的细胞，即少突胶质细胞。活化免疫细胞的浸润和内源性神经胶质细胞的募集导致髓鞘和少突胶质细胞的破坏，这一过程因浸润细胞释放细胞因子而加剧。最近的证据表明，负责破坏髓鞘的关键细胞因子也可能介导髓鞘再生和修复过程。似乎炎症和修复过程都受细胞因子与其靶标的时空关系支配。
