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脑啡肽能脑结构在调节5-羟色胺能神经元损伤大鼠动机行为中的作用

Role of enkephalinergic brain structures in regulating motivated behavior in rats with lesioned serotoninergic neurons.

作者信息

Shugalev N P

机构信息

Laboratory for Conditioned Reflex Morphophysiology, Science Research Institute of the Brain, Russian Academy of Medical Sciences, Moscow, Russia.

出版信息

Neurosci Behav Physiol. 1998 Jul-Aug;28(4):376-9. doi: 10.1007/BF02464790.

DOI:10.1007/BF02464790
PMID:9762707
Abstract

The behavioral effects of injections of enkephalin into the substantia nigra or dorsal raphe nucleus were studied in rats with lesioned serotoninergic structures. Lesions were produced by intracerebral administration of the neurotoxin 5,7-dihydroxytryptamine. Treated rats showed normalization of conditioned drinking reflex extinction. It is proposed that there is a tight connection between the normalizing effects of enkephalin on rat behavior in conditions of deficient brain serotoninergic system function and increases in the efficiency of presynaptic inhibition of dopaminergic neurons.

摘要

在具有受损血清素能结构的大鼠中，研究了向黑质或中缝背核注射脑啡肽的行为效应。通过脑内注射神经毒素5,7 - 二羟基色胺产生损伤。经治疗的大鼠表现出条件性饮水反射消退的正常化。有人提出，在脑血清素能系统功能不足的情况下，脑啡肽对大鼠行为的正常化作用与多巴胺能神经元突触前抑制效率的提高之间存在紧密联系。

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1
Role of enkephalinergic brain structures in regulating motivated behavior in rats with lesioned serotoninergic neurons.脑啡肽能脑结构在调节5-羟色胺能神经元损伤大鼠动机行为中的作用
Neurosci Behav Physiol. 1998 Jul-Aug;28(4):376-9. doi: 10.1007/BF02464790.
2
[Role of enkephalinergic structures of the brain in regulation of motivated behaviour in rats with damaged serotoninergic neurons].[脑内脑啡肽能结构在5-羟色胺能神经元受损大鼠动机行为调节中的作用]
Ross Fiziol Zh Im I M Sechenova. 1997 Jan-Feb;83(1-2):71-5.
3
[The effect of enkephalin on rat behavior after damage to the serotoninergic neurons].[脑啡肽对5-羟色胺能神经元损伤后大鼠行为的影响]
Zh Vyssh Nerv Deiat Im I P Pavlova. 1995 Nov-Dec;45(6):1214-6.
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[Delayed effects of neurotensin microinjections into the substantia nigra on conditioned motor reactions of rats with lesions to serotoninergic neurons].[向黑质微量注射神经降压素对血清素能神经元损伤大鼠条件性运动反应的延迟影响]
Zh Vyssh Nerv Deiat Im I P Pavlova. 2003 Nov-Dec;53(6):802-7.
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5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus alters neuronal activity of the subthalamic nucleus in normal and 6-hydroxydopamine-lesioned rats.中缝背核的5,7-二羟基色胺损伤改变正常及6-羟基多巴胺损伤大鼠丘脑底核的神经元活动。
Brain Res. 2007 May 29;1149:216-22. doi: 10.1016/j.brainres.2007.02.052. Epub 2007 Feb 28.
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Intrastriatal transplants of embryonic dopaminergic neurons counteract the increase of striatal enkephalin immunostaining but not serotoninergic sprouting elicited by a neonatal lesion of the nigrostriatal dopaminergic pathway.胚胎多巴胺能神经元的纹状体内移植可抵消纹状体脑啡肽免疫染色的增加，但不能抵消黑质纹状体多巴胺能通路新生损伤所引发的5-羟色胺能发芽。
Eur J Neurosci. 1993 Feb 1;5(2):128-36. doi: 10.1111/j.1460-9568.1993.tb00478.x.
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Depletion of brain serotonin following intra-raphe injections of 5,7-dihydroxytryptamine does not alter d-amphetamine self-administration across different schedule and access conditions.在中缝内注射5,7-二羟基色胺后，脑内血清素的耗竭不会改变不同给药方案和给药途径下右旋苯丙胺的自我给药情况。
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Opioid receptor-like 1 (NOP) receptors in the rat dorsal raphe nucleus: evidence for localization on serotoninergic neurons and functional adaptation after 5,7-dihydroxytryptamine lesion.大鼠中缝背核中的阿片样受体-1（NOP）受体：5,7-二羟色胺损伤后定位于5-羟色胺能神经元及功能适应性的证据
J Neurosci Res. 2005 Aug 15;81(4):488-96. doi: 10.1002/jnr.20571.
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Interaction of serotonin- and dopaminergic systems of the brain in mechanisms of latent inhibition in rats.大鼠潜在抑制机制中大脑5-羟色胺能与多巴胺能系统的相互作用
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本文引用的文献

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Differential effects of quinpirole in the nucleus accumbens depending on the initial level of locomotor activity.
Brain Res Bull. 1993;32(4):395-8. doi: 10.1016/0361-9230(93)90206-q.
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[The behavioral effects of dopamine agonists in rats following the intrastriatal administration of 6-hydroxydopamine].[6-羟基多巴胺脑内注射后多巴胺激动剂对大鼠行为的影响]
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Dopaminergic regulation of the serotonergic raphe-striatal pathway: microdialysis studies in freely moving rats.多巴胺能对血清素能中缝核 - 纹状体通路的调节：对自由活动大鼠的微透析研究
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Facilitation of a dendritic calcium conductance by 5-hydroxytryptamine in the substantia nigra.5-羟色胺对黑质中树突状钙电导的促进作用。
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[The effect of serotonin and dopamine microinjections into the dorsal raphe nucleus on the extinction of a conditioned reflex in rats].[向大鼠中缝背核微量注射血清素和多巴胺对条件反射消退的影响]
Zh Vyssh Nerv Deiat Im I P Pavlova. 1992 Mar-Apr;42(2):384-6.