异舒普林对无髓神经纤维的作用。

The effects of isoxsuprine on non-myelinated nerve fibres.

作者信息

Hertog A

出版信息

Eur J Pharmacol. 1976 Oct;39(2):283-6. doi: 10.1016/0014-2999(76)90137-0.

Abstract

A study has been made of the effect of isoxsuprine on non-myelinated nerve fibres of the desheathed rabbit vagus. Isoxsuprine did not affect the membrane potential, the membrane resistance, or the sodium pump activity. Isoxsuprine diminished the amplitude and rise time of the compound action potential. This indicates that isoxsuprine decreased the peak sodium current during the action potential. This local anesthetic action of isoxsupring is more pronounced than that of lidocaine.

摘要

一项关于异克舒令对去鞘兔迷走神经无髓鞘神经纤维作用的研究已经完成。异克舒令不影响膜电位、膜电阻或钠泵活性。异克舒令减小了复合动作电位的幅度和上升时间。这表明异克舒令降低了动作电位期间的峰值钠电流。异克舒令的这种局部麻醉作用比利多卡因更明显。