Taberner P V
Eur J Pharmacol. 1976 Oct;39(2):305-11. doi: 10.1016/0014-2999(76)90140-0.
The activity of the dissociative anaesthetics ketamine and gamma-hydroxybutyrate against seizures induced by mercaptopropionate and pentylenetetrazol have been determined. Ketamine (90 mg/kg) prevented the seizures induced by both convulsants, but gamma-hydroxybutyrate had negligible anticonvulsant activity. Mercaptopropionate (150 mg/kg) produced a rapid fall in whole brain glutamate decarboxylase activity which correlated with the onset of convulsions. Ketamine given prior to the mercaptopropionate prevented the convulsions, but had no effect on the reduction of enzyme activity. It was concluded that although ketamine was an anticonvulsant it did not act by preventing the inhibition of glutamate decarboxylase responsible for mercaptopropionate-induced convulsions.
已测定了分离麻醉剂氯胺酮和γ-羟基丁酸对巯基丙酸盐和戊四氮诱发癫痫发作的作用。氯胺酮（90毫克/千克）可预防两种惊厥剂诱发的癫痫发作，但γ-羟基丁酸的抗惊厥活性可忽略不计。巯基丙酸盐（150毫克/千克）可使全脑谷氨酸脱羧酶活性迅速下降，这与惊厥发作的开始相关。在给予巯基丙酸盐之前给予氯胺酮可预防惊厥发作，但对酶活性的降低没有影响。得出的结论是，尽管氯胺酮是一种抗惊厥剂，但其作用并非通过防止负责巯基丙酸盐诱发惊厥的谷氨酸脱羧酶受到抑制来实现。
