组胺受体介导的富含受体的微粒体组分中的钙离子移动。

Histamine receptor-mediated calcium ion movement in a receptor-rich microsomal fraction.

作者信息

Uchida M, Takagi K

出版信息

Eur J Pharmacol. 1976 Oct;39(2):413-6. doi: 10.1016/0014-2999(76)90154-0.

Abstract

The histamine receptor-rich microsomal fraction from the longitudinal muscle of cat small intestine, which consists of membrane vesicles, was loaded with 45Ca ions and the Ca ion efflux from it was examined. Histamine increased the efflux of 45Ca ions. The effect of histamine was blocked by diphenhydramine. Histamine had no effect on the histamine receptor-free microsomal fraction from dog small intestine muscle. This suggests that the ion movement may be mediated by histamine receptors.

摘要

取自猫小肠纵肌富含组胺受体的微粒体部分（由膜囊泡构成）被加载了45Ca离子，并检测了其中Ca离子的流出情况。组胺增加了45Ca离子的流出。组胺的作用被苯海拉明阻断。组胺对取自犬小肠肌无组胺受体的微粒体部分没有影响。这表明离子移动可能是由组胺受体介导的。